Cargando…

The prohibitin-binding compound fluorizoline induces apoptosis in chronic lymphocytic leukemia cells through the upregulation of NOXA and synergizes with ibrutinib, 5-aminoimidazole-4-carboxamide riboside or venetoclax

Fluorizoline is a new synthetic molecule that induces apoptosis by selectively targeting prohibitins. In the study herein, the pro-apoptotic effect of fluorizoline was assessed in 34 primary samples from patients with chronic lymphocytic leukemia. Fluorizoline induced apoptosis in chronic lymphocyti...

Descripción completa

Detalles Bibliográficos
Autores principales:	Cosialls, Ana M., Pomares, Helena, Iglesias-Serret, Daniel, Saura-Esteller, José, Núñez-Vázquez, Sonia, González-Gironès, Diana M., de la Banda, Esmeralda, Preciado, Sara, Albericio, Fernando, Lavilla, Rodolfo, Pons, Gabriel, González-Barca, Eva M., Gil, Joan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Ferrata Storti Foundation 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5685241/ https://www.ncbi.nlm.nih.gov/pubmed/28619845 http://dx.doi.org/10.3324/haematol.2016.162958

Ejemplares similares

The prohibitin-binding compound fluorizoline inhibits mitophagy in cancer cells
por: Núñez-Vázquez, Sonia, et al.
Publicado: (2021)

A novel prohibitin-binding compound induces the mitochondrial apoptotic pathway through NOXA and BIM upregulation
por: Moncunill-Massaguer, Cristina, et al.
Publicado: (2015)

The Prohibitin-Binding Compound Fluorizoline Activates the Integrated Stress Response through the eIF2α Kinase HRI
por: Sánchez-Vera, Ismael, et al.
Publicado: (2023)

Targeting prohibitins induces apoptosis in acute myeloid leukemia cells
por: Pomares, Helena, et al.
Publicado: (2016)

Activation of the Integrated Stress Response and ER Stress Protect from Fluorizoline-Induced Apoptosis in HEK293T and U2OS Cell Lines
por: Saura-Esteller, José, et al.
Publicado: (2021)

Aspirin and 5-Aminoimidazole-4-carboxamide Riboside Attenuate Bovine Ephemeral Fever Virus Replication by Inhibiting BEFV-Induced Autophagy
por: Tseng, Hsu-Hung, et al.
Publicado: (2020)

5-aminoimidazole-4-carboxamide Riboside Induces Apoptosis Through AMP-activated Protein Kinase-independent and NADPH Oxidase-dependent Pathways
por: Wi, Sae Mi, et al.
Publicado: (2014)

Solid-Phase Synthesis of a New Diphosphate 5-Aminoimidazole-4-carboxamide Riboside (AICAR) Derivative and Studies toward Cyclic AICAR Diphosphate Ribose
por: D’Errico, Stefano, et al.
Publicado: (2011)

Insulin and 5-Aminoimidazole-4-Carboxamide Ribonucleotide (AICAR) Differentially Regulate the Skeletal Muscle Cell Secretome
por: Gonzalez-Franquesa, Alba, et al.
Publicado: (2021)

Aminoimidazole Carboxamide Ribonucleotide (AICAR) Inhibits the Growth of Retinoblastoma In Vivo by Decreasing Angiogenesis and Inducing Apoptosis
por: Theodoropoulou, Sofia, et al.
Publicado: (2013)

Synthesis and Behavior of DNA Oligomers Containing the Ambiguous Z-Nucleobase 5-Aminoimidazole-4-carboxamide
por: Nogi, Yuhei, et al.
Publicado: (2023)

Effects of intravenous AICAR (5-aminoimidazole-4-carboximide riboside) administration on insulin signaling and resistance in premature baboons, Papio sp.
por: Blanco, Cynthia L., et al.
Publicado: (2018)

Association of the 5-aminoimidazole-4-carboxamide ribonucleotide transformylase gene with response to methotrexate in juvenile idiopathic arthritis
por: Hinks, Anne, et al.
Publicado: (2011)

5-Aminoimidazole-4-carboxamide ribonucleoside-induced autophagy flux during differentiation of monocytic leukemia cells
por: Dembitz, Vilma, et al.
Publicado: (2017)

Untargeted metabolomics confirms and extends the understanding of the impact of aminoimidazole carboxamide ribotide (AICAR) in the metabolic network of Salmonella enterica
por: Bazurto, Jannell V., et al.
Publicado: (2017)

5-aminoimidazole-4-carboxamide ribonucleoside induces differentiation in a subset of primary acute myeloid leukemia blasts
por: Dembitz, Vilma, et al.
Publicado: (2020)

Influence of Reduced Folate Carrier and Aminoimidazole Carboxamide Ribonucleotide Transformylase gene polymorphisms on the efficacy of methotrexate in juvenile idiopathic arthritis
por: Bilginer, Yelda, et al.
Publicado: (2011)

The effect of 5-aminoimidazole-4-carboxamide ribonucleoside (AICAR) on fatty acid oxidation in hepatocytes isolated from neonatal piglets
por: Xi, Lin, et al.
Publicado: (2012)

The AMPK agonist 5‐aminoimidazole‐4‐carboxamide ribonucleotide (AICAR), but not metformin, prevents inflammation‐associated cachectic muscle wasting
por: Hall, Derek T, et al.
Publicado: (2018)

Enhancement of insulin-mediated rat muscle glucose uptake and microvascular perfusion by 5-aminoimidazole-4-carboxamide-1-β-d-ribofuranoside
por: Bradley, Eloise A, et al.
Publicado: (2015)

5-Aminoimidazole-4-carboxamide-1-beta-D-ribofuranosyl 5'-Monophosphate (AICAR), a Highly Conserved Purine Intermediate with Multiple Effects
por: Daignan-Fornier, Bertrand, et al.
Publicado: (2012)

Involvement of both caspase-8 and Noxa-activated pathways in endoplasmic reticulum stress-induced apoptosis in triple-negative breast tumor cells
por: Cano-González, Ana, et al.
Publicado: (2018)

5-aminoimidazole-4-carboxamide-1-beta-4-ribofuranoside (AICAR) attenuates the expression of LPS- and Aβ peptide-induced inflammatory mediators in astroglia
por: Ayasolla, Kamesh R, et al.
Publicado: (2005)

The effect of 5-aminoimidazole-4-carboxamide-ribonucleoside was mediated by p38 mitogen activated protein kinase signaling pathway in FRO thyroid cancer cells
por: Kim, Won Gu, et al.
Publicado: (2014)

Nicotinamide Riboside and Dihydronicotinic Acid Riboside Synergistically Increase Intracellular NAD(+) by Generating Dihydronicotinamide Riboside
por: Ciarlo, Eleonora, et al.
Publicado: (2022)

Cytotoxic effect of 5-aminoimidazole-4-carboxamide-1-β-4-ribofuranoside (AICAR) on childhood acute lymphoblastic leukemia (ALL) cells: implication for targeted therapy
por: Sengupta, Tapas K, et al.
Publicado: (2007)

Effect of Deer Antler Extract on Muscle Differentiation and 5-Aminoimidazole-4-Carboxamide Ribonucleoside (AICAR)-Induced Muscle Atrophy in C2C12 Cells
por: Jo, Kyungae, et al.
Publicado: (2021)

5-aminoimidazole-4-carboxamide ribonucleotide-transformylase and inosine-triphosphate-pyrophosphatase genes variants predict remission rate during methotrexate therapy in patients with juvenile idiopathic arthritis
por: Pastore, Serena, et al.
Publicado: (2014)

Optimization of Aminoimidazole Derivatives as Src Family Kinase Inhibitors
por: Francini, Cinzia Maria, et al.
Publicado: (2018)

The effects of in ovo nicotinamide riboside dose on broiler myogenesis
por: Xu, Xiaoxing, et al.
Publicado: (2020)

AMPK Activation by 5-Amino-4-Imidazole Carboxamide Riboside-1-β-D-Ribofuranoside Attenuates Alkali Injury-Induced Corneal Fibrosis
por: Nuwormegbe, Selikem Abla, et al.
Publicado: (2020)

Dihydronicotinamide riboside: synthesis from nicotinamide riboside chloride, purification and stability studies
por: Zarei, Amin, et al.
Publicado: (2021)

Prohibitin-1 Transgenic Mice Revealed an Important Role of Prohibitin in Testicular Steroidogenesis
por: Bassi, Geetika, et al.
Publicado: (2021)

The Adenosine Monophosphate (AMP) Analog, 5-Aminoimidazole-4-Carboxamide Ribonucleotide (AICAR) Inhibits Hepatosteatosis and Liver Tumorigenesis in a High-Fat Diet Murine Model Treated with Diethylnitrosamine (DEN)
por: Gao, Jianlong, et al.
Publicado: (2018)

One-carbon metabolizing enzyme ALDH1L1 influences mitochondrial metabolism through 5-aminoimidazole-4-carboxamide ribonucleotide accumulation and serine depletion, contributing to tumor suppression
por: Sasaki, Masato, et al.
Publicado: (2023)

Enhanced Nonenzymatic RNA Copying with 2-Aminoimidazole Activated Nucleotides
por: Li, Li, et al.
Publicado: (2017)

An Expeditious and Greener Synthesis of 2-Aminoimidazoles in Deep Eutectic Solvents
por: Capua, Martina, et al.
Publicado: (2016)

Synthesis of Pyridoxine-Derived Dimethylpyridinols Fused with Aminooxazole, Aminoimidazole, and Aminopyrrole
por: Awasthi, Bhuwan Prasad, et al.
Publicado: (2022)

Sensitization of Gram-Negative Bacteria to Aminoglycosides with 2-Aminoimidazole Adjuvants
por: Crotteau, Ashley N., et al.
Publicado: (2023)

Rationale for the combination of venetoclax and ibrutinib in T-prolymphocytic leukemia
por: Kornauth, Christoph, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_httbko81bvjoudsjml6hhll9aa