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Sustained Intracellular Acidosis Triggers the Na(+)/H(+) Exchager-1 Activation in Glutamate Excitotoxicity
The Na(+)/H(+) exchanger-1 (NHE-1) is a ubiquitously expressed pH-regulatory membrane protein that functions in the brain, heart, and other organs. It is increased by intracellular acidosis through the interaction of intracellular H(+) with an allosteric modifier site in the transport domain. In the...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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The Korean Society of Applied Pharmacology
2017
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5685428/ https://www.ncbi.nlm.nih.gov/pubmed/28605830 http://dx.doi.org/10.4062/biomolther.2017.018 |