Cargando…

Metformin extends C. elegans lifespan through lysosomal pathway

Metformin, a widely used first-line drug for treatment of type 2 diabetes (T2D), has been shown to extend lifespan and delay the onset of age-related diseases. However, its primary locus of action remains unclear. Using a pure in vitro reconstitution system, we demonstrate that metformin acts throug...

Descripción completa

Detalles Bibliográficos
Autores principales: Chen, Jie, Ou, Yuhui, Li, Yi, Hu, Shumei, Shao, Li-Wa, Liu, Ying
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5685485/
https://www.ncbi.nlm.nih.gov/pubmed/29027899
http://dx.doi.org/10.7554/eLife.31268