Regional knockdown of NDUFS4 implicates a thalamocortical circuit mediating anesthetic sensitivity

Knockout of the mitochondrial complex I protein, NDUFS4, profoundly increases sensitivity of mice to volatile anesthetics. In mice carrying an Ndufs4(lox/lox) gene, adeno-associated virus expressing Cre recombinase was injected into regions of the brain postulated to affect sensitivity to volatile a...

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Detalles Bibliográficos
Autores principales: Ramadasan-Nair, Renjini, Hui, Jessica, Zimin, Pavel I., Itsara, Leslie S., Morgan, Philip G., Sedensky, Margaret M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5685608/
https://www.ncbi.nlm.nih.gov/pubmed/29136012
http://dx.doi.org/10.1371/journal.pone.0188087

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5685608/
https://www.ncbi.nlm.nih.gov/pubmed/29136012
http://dx.doi.org/10.1371/journal.pone.0188087

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