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Regional knockdown of NDUFS4 implicates a thalamocortical circuit mediating anesthetic sensitivity
Knockout of the mitochondrial complex I protein, NDUFS4, profoundly increases sensitivity of mice to volatile anesthetics. In mice carrying an Ndufs4(lox/lox) gene, adeno-associated virus expressing Cre recombinase was injected into regions of the brain postulated to affect sensitivity to volatile a...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5685608/ https://www.ncbi.nlm.nih.gov/pubmed/29136012 http://dx.doi.org/10.1371/journal.pone.0188087 |