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E3 ligase mahogunin (MGRN1) influences amyloid precursor protein maturation and secretion

Altered processing of the Amyloid Precursor Protein (APP) is a well-recognized central pathogenic mechanism in Alzheimer's Disease (AD), and regulation of APP processing is a major focus of research in the AD field. However, how age-associated cellular and molecular changes contribute to change...

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Detalles Bibliográficos
Autores principales: Benvegnù, Stefano, Wahle, Tina, Dotti, Carlos G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5685682/
https://www.ncbi.nlm.nih.gov/pubmed/29163761
http://dx.doi.org/10.18632/oncotarget.20143