BMI1 reduces ATR activation and signalling caused by hydroxyurea

BMI1 facilitates DNA damage response (DDR) induced by double strand DNA breaks; however, it remains unknown whether BMI1 functions in single strand DNA (ssDNA) lesions-initiated DDR. We report here that BMI1 reduces hydroxyurea-elicited ATR activation, thereby reducing the S-phase checkpoints. Hydro...

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Detalles Bibliográficos
Autores principales: Lin, Xiaozeng, Wei, Fengxiang, Whyte, Peter, Tang, Damu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5685703/
https://www.ncbi.nlm.nih.gov/pubmed/29163782
http://dx.doi.org/10.18632/oncotarget.21111

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5685703/
https://www.ncbi.nlm.nih.gov/pubmed/29163782
http://dx.doi.org/10.18632/oncotarget.21111

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