Cargando…

Oral 4-(N)-stearoyl gemcitabine nanoparticles inhibit tumor growth in mouse models

In spite of recent advances in targeted tumor therapy, systemic chemotherapy with cytotoxic agents remains a vital cancer treatment modality. Gemcitabine is a nucleoside analog commonly used in the treatment of various solid tumors, but an oral gemcitabine dosage form remain unavailable. Previously,...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wang, Caixia, Zheng, Yuanqiang, Sand oval, Michael A., Valdes, Solange A., Chen, Zhe, Lansakara-P, Dharmika S., Du, Maolin, Shi, Yanchun, Cui, Zhengrong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2017
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5685716/ https://www.ncbi.nlm.nih.gov/pubmed/29163795 http://dx.doi.org/10.18632/oncotarget.21264

Ejemplares similares

Overcoming tumor cell chemoresistance using nanoparticles: lysosomes are beneficial for (stearoyl) gemcitabine-incorporated solid lipid nanoparticles
por: Chen, Zhe, et al.
Publicado: (2018)

Synthesis, Characterization, and In Vitro and In Vivo Evaluations of 4-(N)-Docosahexaenoyl 2′, 2′-Difluorodeoxycytidine with Potent and Broad-Spectrum Antitumor Activity()()
por: Naguib, Youssef W., et al.
Publicado: (2016)

Stearoyl-Chitosan Coated Nanoparticles Obtained by Microemulsion Cold Dilution Technique
por: Chirio, Daniela, et al.
Publicado: (2018)

Effect of nanoparticle size on their distribution and retention in chronic inflammation sites
por: Aldayel, Abdulaziz M., et al.
Publicado: (2023)

Chitosan–Pluronic nanoparticles as oral delivery of anticancer gemcitabine: preparation and in vitro study
por: Hosseinzadeh, Hosniyeh, et al.
Publicado: (2012)

Regulation of mitochondrial morphology and function by Stearoylation of TfR1
por: Senyilmaz, Deniz, et al.
Publicado: (2015)

Stearoyl-CoA Desaturase inhibition reverses immune, synaptic and cognitive impairments in an Alzheimer’s disease mouse model
por: Hamilton, Laura K., et al.
Publicado: (2022)

Inhibition of stearoyl CoA desaturase‐1 activity suppresses tumour progression and improves prognosis in human bladder cancer
por: Piao, Chiyuan, et al.
Publicado: (2018)

The Evolutionary Pattern and the Regulation of Stearoyl-CoA Desaturase Genes
por: Wu, Xiaoyun, et al.
Publicado: (2013)

Stearoyl-CoA Desaturase Is Essential for Porcine Adipocyte Differentiation
por: Liu, Lulu, et al.
Publicado: (2020)

Synthesis of Superhydrophobic Cellulose Stearoyl Ester for Oil/Water Separation
por: Yang, Qian, et al.
Publicado: (2022)

Role of Stearoyl-CoA Desaturase 1 in Cardiovascular Physiology
por: Balatskyi, Volodymyr V., et al.
Publicado: (2023)

Physicochemical Properties and Release Study of Antimetabolite-Incorporated Stearoyl Chitosan
por: Marlina, Anita, et al.
Publicado: (2023)

Discovery of Tumor-Specific Irreversible Inhibitors of Stearoyl CoA Desaturase
por: Theodoropoulos, Panayotis C., et al.
Publicado: (2016)

The evolutionary history of the stearoyl-CoA desaturase gene family in vertebrates
por: Castro, L Filipe C, et al.
Publicado: (2011)

Elevated Stearoyl-CoA Desaturase in Brains of Patients with Alzheimer's Disease
por: Astarita, Giuseppe, et al.
Publicado: (2011)

X-ray Structure of a Mammalian Stearoyl-CoA Desaturase
por: Bai, Yonghong, et al.
Publicado: (2015)

Stearoyl-CoA Desaturase-2 in Murine Development, Metabolism, and Disease
por: O’Neill, Lucas M., et al.
Publicado: (2020)

Development and Characterization of Nanoparticles for the Delivery of Gemcitabine Hydrochloride
por: Khaira, Rekha, et al.
Publicado: (2014)

Fabrication and Cytotoxicity of Gemcitabine-Functionalized Magnetite Nanoparticles
por: Popescu, Roxana Cristina, et al.
Publicado: (2017)

Mechanisms of stearoyl CoA desaturase inhibitor sensitivity and acquired resistance in cancer
por: Oatman, Nicole, et al.
Publicado: (2021)

Effects of CRISPR/Cas9-mediated stearoyl-Coenzyme A desaturase 1 knockout on mouse embryo development and lipid synthesis
por: Tian, Huibin, et al.
Publicado: (2022)

Author Correction: Stearoyl-CoA Desaturase inhibition reverses immune, synaptic and cognitive impairments in an Alzheimer’s disease mouse model
por: Hamilton, Laura K., et al.
Publicado: (2023)

Regulation of lipid droplet size and phospholipid composition by stearoyl-CoA desaturase
por: Shi, Xun, et al.
Publicado: (2013)

Moisture-responsive films of cellulose stearoyl esters showing reversible shape transitions
por: Zhang, Kai, et al.
Publicado: (2015)

Targeting stearoyl-CoA desaturase 1 to repress endometrial cancer progression
por: Li, Weihua, et al.
Publicado: (2018)

Stearoyl-CoA Desaturase 1 as a Therapeutic Target for the Treatment of Cancer
por: Tracz-Gaszewska, Zuzanna, et al.
Publicado: (2019)

Melting, Crystallization, and In Vitro Digestion Properties of Fats Containing Stearoyl-Rich Triacylglycerols
por: Shin, Kwang-Seup, et al.
Publicado: (2021)

Stearoyl-CoA Desaturase Regulates Angiogenesis and Energy Metabolism in Ischemic Cardiomyocytes
por: Gan, Ana-Maria, et al.
Publicado: (2022)

Sodium stearoyl glutamate: Another amino acid alkyl amide sensitizer in cosmetics
por: Pralong, Pauline, et al.
Publicado: (2022)

Loss of stearoyl-CoA desaturase 2 disrupts inflammatory response in macrophages
por: Lin, Joseph B., et al.
Publicado: (2023)

Increased expression of the gene encoding stearoyl-CoA desaturase 1 in human bladder cancer
por: Presler, M., et al.
Publicado: (2018)

Permeation of antigen protein-conjugated nanoparticles and live bacteria through microneedle-treated mouse skin
por: Kumar, Amit, et al.
Publicado: (2011)

Gold Nanoparticles sensitize pancreatic cancer cells to gemcitabine
por: Huai, Yanyan, et al.
Publicado: (2019)

Delivery of Gemcitabine Prodrugs Employing Mesoporous Silica Nanoparticles
por: Malfanti, Alessio, et al.
Publicado: (2016)

Stearoyl-CoA desaturase-1 is a key factor for lung cancer-initiating cells
por: Noto, A, et al.
Publicado: (2013)

Stearoyl-CoA desaturase-1 impairs the reparative properties of macrophages and microglia in the brain
por: Bogie, Jeroen F.J., et al.
Publicado: (2020)

Stearoyl-CoA Desaturase-Mediated Monounsaturated Fatty Acid Availability Supports Humoral Immunity
por: Zhou, Xian, et al.
Publicado: (2021)

Permeability of Gemcitabine and PBPK Modeling to Assess Oral Administration
por: Ferreira, Abigail, et al.
Publicado: (2021)

Gemcitabine-Loaded Albumin Nanoparticle Exerts An Antitumor Effect on Gemcitabine-Resistant Pancreatic Cancer Cells Induced by MDR1 and MRP1 Overexpression in Vitro
por: Kong, Lei, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_lv0fl18jpgjgln4prhh91039r0