MYC is downregulated by a mitochondrial checkpoint mechanism

The MYC proto-oncogene serves as a rheostat coupling mitogenic signaling with the activation of genes regulating growth, metabolism and mitochondrial biogenesis. Here we describe a novel link between mitochondria and MYC levels. Perturbation of mitochondrial function using a number of conventional a...

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Detalles Bibliográficos
Autores principales: Zhang, Xiaonan, Mofers, Arjan, Hydbring, Per, Olofsson, Maria Hägg, Guo, Jing, Linder, Stig, D'Arcy, Padraig
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5685744/
https://www.ncbi.nlm.nih.gov/pubmed/29163823
http://dx.doi.org/10.18632/oncotarget.21653

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5685744/
https://www.ncbi.nlm.nih.gov/pubmed/29163823
http://dx.doi.org/10.18632/oncotarget.21653

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