Cargando…
MYC is downregulated by a mitochondrial checkpoint mechanism
The MYC proto-oncogene serves as a rheostat coupling mitogenic signaling with the activation of genes regulating growth, metabolism and mitochondrial biogenesis. Here we describe a novel link between mitochondria and MYC levels. Perturbation of mitochondrial function using a number of conventional a...
Autores principales: | Zhang, Xiaonan, Mofers, Arjan, Hydbring, Per, Olofsson, Maria Hägg, Guo, Jing, Linder, Stig, D'Arcy, Padraig |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Impact Journals LLC
2017
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5685744/ https://www.ncbi.nlm.nih.gov/pubmed/29163823 http://dx.doi.org/10.18632/oncotarget.21653 |
Ejemplares similares
-
Proteasome-associated deubiquitinases and cancer
por: Mofers, Arjan, et al.
Publicado: (2017) -
Targeting Mitochondrial Function to Treat Quiescent Tumor Cells in Solid Tumors
por: Zhang, Xiaonan, et al.
Publicado: (2015) -
Analysis of determinants for in vitro resistance to the small molecule deubiquitinase inhibitor b-AP15
por: Mofers, Arjan, et al.
Publicado: (2019) -
Acute lymphoblastic leukemia cells are sensitive to disturbances in protein homeostasis induced by proteasome deubiquitinase inhibition
por: Mazurkiewicz, Magdalena, et al.
Publicado: (2017) -
Induction of ER Stress in Acute Lymphoblastic Leukemia Cells by the Deubiquitinase Inhibitor VLX1570
por: Pellegrini, Paola, et al.
Publicado: (2020)