Ca(2+) signals initiate at immobile IP(3) receptors adjacent to ER-plasma membrane junctions

IP(3) receptors (IP(3)Rs) release Ca(2+) from the ER when they bind IP(3) and Ca(2+). The spatial organization of IP(3)Rs determines both the propagation of Ca(2+) signals between IP(3)Rs and the selective regulation of cellular responses. Here we use gene editing to fluorescently tag endogenous IP(...

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Detalles Bibliográficos
Autores principales: Thillaiappan, Nagendra Babu, Chavda, Alap P., Tovey, Stephen C., Prole, David L., Taylor, Colin W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5686115/
https://www.ncbi.nlm.nih.gov/pubmed/29138405
http://dx.doi.org/10.1038/s41467-017-01644-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5686115/
https://www.ncbi.nlm.nih.gov/pubmed/29138405
http://dx.doi.org/10.1038/s41467-017-01644-8

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