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Ca(2+) signals initiate at immobile IP(3) receptors adjacent to ER-plasma membrane junctions
IP(3) receptors (IP(3)Rs) release Ca(2+) from the ER when they bind IP(3) and Ca(2+). The spatial organization of IP(3)Rs determines both the propagation of Ca(2+) signals between IP(3)Rs and the selective regulation of cellular responses. Here we use gene editing to fluorescently tag endogenous IP(...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5686115/ https://www.ncbi.nlm.nih.gov/pubmed/29138405 http://dx.doi.org/10.1038/s41467-017-01644-8 |