The Semaphorin 3A inhibitor SM-345431 preserves corneal nerve and epithelial integrity in a murine dry eye model

Dry eye disease (DED) is a common disorder causing discomfort and ocular fatigue. Corneal nerves are compromised in DED, which may further cause loss of corneal sensation and decreased tear secretion. Semaphorin 3A (Sema3A) is expressed by the corneal epithelium under stress, and is known as an inhi...

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Detalles Bibliográficos
Autores principales: Yamazaki, Risa, Yamazoe, Katsuya, Yoshida, Satoru, Hatou, Shin, Inagaki, Emi, Okano, Hideyuki, Tsubota, Kazuo, Shimmura, Shigeto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5686158/
https://www.ncbi.nlm.nih.gov/pubmed/29138447
http://dx.doi.org/10.1038/s41598-017-15682-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5686158/
https://www.ncbi.nlm.nih.gov/pubmed/29138447
http://dx.doi.org/10.1038/s41598-017-15682-1

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