Structure-function relationships in ABCG2: insights from molecular dynamics simulations and molecular docking studies

Efflux pumps of the ATP-binding cassette transporters superfamily (ABC transporters) are frequently involved in the multidrug-resistance (MDR) phenomenon in cancer cells. Herein, we describe a new atomistic model for the MDR-related ABCG2 efflux pump, also named breast cancer resistance protein (BCR...

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Detalles Bibliográficos
Autores principales: Ferreira, Ricardo J., Bonito, Cátia A., Cordeiro, M. Natália D. S., Ferreira, Maria-José U., dos Santos, Daniel J. V. A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5686161/
https://www.ncbi.nlm.nih.gov/pubmed/29138424
http://dx.doi.org/10.1038/s41598-017-15452-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5686161/
https://www.ncbi.nlm.nih.gov/pubmed/29138424
http://dx.doi.org/10.1038/s41598-017-15452-z

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