Phagocytosis of environmental or metabolic crystalline particles induces cytotoxicity by triggering necroptosis across a broad range of particle size and shape

In crystallopathies, crystals or crystalline particles of environmental and metabolic origin deposit within tissues, induce inflammation, injury and cell death and eventually lead to organ-failure. The NLRP3-inflammasome is involved in mediating crystalline particles-induced inflammation, but pathwa...

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Detalles Bibliográficos
Autores principales: Honarpisheh, Mohsen, Foresto-Neto, Orestes, Desai, Jyaysi, Steiger, Stefanie, Gómez, Lidia Anguiano, Popper, Bastian, Boor, Peter, Anders, Hans-Joachim, Mulay, Shrikant R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5686194/
https://www.ncbi.nlm.nih.gov/pubmed/29138474
http://dx.doi.org/10.1038/s41598-017-15804-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5686194/
https://www.ncbi.nlm.nih.gov/pubmed/29138474
http://dx.doi.org/10.1038/s41598-017-15804-9

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