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Bidirectional modulation of hippocampal synaptic plasticity by Dopaminergic D4-receptors in the CA1 area of hippocampus

Long-term potentiation (LTP) is the persistent increase in the strength of the synapses. However, the neural networks would become saturated if there is only synaptic strenghthening. Synaptic weakening could be facilitated by active processes like long-term depression (LTD). Molecular mechanisms tha...

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Detalles Bibliográficos
Autores principales: Navakkode, Sheeja, Chew, Katherine C. M., Tay, Sabrina Jia Ning, Lin, Qingshu, Behnisch, Thomas, Soong, Tuck Wah
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5686203/
https://www.ncbi.nlm.nih.gov/pubmed/29138490
http://dx.doi.org/10.1038/s41598-017-15917-1