Model selection and averaging of nonlinear mixed-effect models for robust phase III dose selection

Population model-based (pharmacometric) approaches are widely used for the analyses of phase IIb clinical trial data to increase the accuracy of the dose selection for phase III clinical trials. On the other hand, if the analysis is based on one selected model, model selection bias can potentially s...

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Detalles Bibliográficos
Autores principales: Aoki, Yasunori, Röshammar, Daniel, Hamrén, Bengt, Hooker, Andrew C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2017
Materias:
Original Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5686275/
https://www.ncbi.nlm.nih.gov/pubmed/29103208
http://dx.doi.org/10.1007/s10928-017-9550-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5686275/
https://www.ncbi.nlm.nih.gov/pubmed/29103208
http://dx.doi.org/10.1007/s10928-017-9550-0

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