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Model selection and averaging of nonlinear mixed-effect models for robust phase III dose selection
Population model-based (pharmacometric) approaches are widely used for the analyses of phase IIb clinical trial data to increase the accuracy of the dose selection for phase III clinical trials. On the other hand, if the analysis is based on one selected model, model selection bias can potentially s...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Springer US
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5686275/ https://www.ncbi.nlm.nih.gov/pubmed/29103208 http://dx.doi.org/10.1007/s10928-017-9550-0 |