An automated sampling importance resampling procedure for estimating parameter uncertainty

Quantifying the uncertainty around endpoints used for decision-making in drug development is essential. In nonlinear mixed-effects models (NLMEM) analysis, this uncertainty is derived from the uncertainty around model parameters. Different methods to assess parameter uncertainty exist, but scrutiny...

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Detalles Bibliográficos
Autores principales: Dosne, Anne-Gaëlle, Bergstrand, Martin, Karlsson, Mats O.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2017
Materias:
Original Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5686280/
https://www.ncbi.nlm.nih.gov/pubmed/28887735
http://dx.doi.org/10.1007/s10928-017-9542-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5686280/
https://www.ncbi.nlm.nih.gov/pubmed/28887735
http://dx.doi.org/10.1007/s10928-017-9542-0

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