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Eukaryotic-type serine/threonine kinase mediated phosphorylation at Thr(169) perturbs mycobacterial guanylate kinase activity
Guanylate kinase is an essential and conserved enzyme in nucleotide biosynthetic pathway that transfers phosphoryl group of ATP to GMP for yielding GDP. Here, we report the phosphorylation of guanylate kinase from Mycobacterium tuberculosis (mGmk) by eukaryotic-type Ser/Thr kinase, PknA. Mass spectr...
Autores principales: | S. Yadav, Ghanshyam, K. Ravala, Sandeep, Kachhap, Sangita, Thakur, Meghna, Roy, Abhishek, Singh, Balvinder, Karthikeyan, Subramanian, K. Chakraborti, Pradip |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Portland Press Ltd.
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5686395/ https://www.ncbi.nlm.nih.gov/pubmed/28963370 http://dx.doi.org/10.1042/BSR20171048 |
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