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Refactoring the Genetic Code for Increased Evolvability
The standard genetic code is robust to mutations during transcription and translation. Point mutations are likely to be synonymous or to preserve the chemical properties of the original amino acid. Saturation mutagenesis experiments suggest that in some cases the best-performing mutant requires repl...
Autores principales: | Pines, Gur, Winkler, James D., Pines, Assaf, Gill, Ryan T. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Society for Microbiology
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5686537/ https://www.ncbi.nlm.nih.gov/pubmed/29138304 http://dx.doi.org/10.1128/mBio.01654-17 |
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