Human hyaluronic acid synthase-1 promotes malignant transformation via epithelial-to-mesenchymal transition, micronucleation and centrosome abnormalities

BACKGROUND: Human hyaluronic acid (HA) molecules are synthesized by three membrane spanning Hyaluronic Acid Synthases (HAS1, HAS2 and HAS3). Of the three, HAS1 is found to be localized more into the cytoplasmic space where it synthesizes intracellular HA. HA is a ubiquitous glycosaminoglycan, mainly...

Descripción completa

Detalles Bibliográficos
Autores principales: Nguyen, Nguyet, Kumar, Awanit, Chacko, Simi, Ouellette, Rodney J., Ghosh, Anirban
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5686803/
https://www.ncbi.nlm.nih.gov/pubmed/29137675
http://dx.doi.org/10.1186/s12964-017-0204-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5686803/
https://www.ncbi.nlm.nih.gov/pubmed/29137675
http://dx.doi.org/10.1186/s12964-017-0204-z

Ejemplares similares