Differential mast cell outcomes are sensitive to FcεRI-Syk binding kinetics

Cross-linking of immunoglobulin E–bound FcεRI triggers multiple cellular responses, including degranulation and cytokine production. Signaling is dependent on recruitment of Syk via docking of its dual SH2 domains to phosphorylated tyrosines within the FcεRI immunoreceptor tyrosine-based activation...

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Detalles Bibliográficos
Autores principales: Schwartz, Samantha L., Cleyrat, Cédric, Olah, Mark J., Relich, Peter K., Phillips, Genevieve K., Hlavacek, William S., Lidke, Keith A., Wilson, Bridget S., Lidke, Diane S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society for Cell Biology 2017
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5687039/
https://www.ncbi.nlm.nih.gov/pubmed/28855374
http://dx.doi.org/10.1091/mbc.E17-06-0350

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5687039/
https://www.ncbi.nlm.nih.gov/pubmed/28855374
http://dx.doi.org/10.1091/mbc.E17-06-0350

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