Crosstalk of LKB1‐regulated and PTEN‐regulated signals in liver morphogenesis and tumor development in mice

Liver kinase B 1 (LKB1 or STK11) and phosphatase and tensin homologue deleted on chromosome 10 (PTEN) are two tumor suppressors that regulate the mammalian target of rapamycin signaling pathway. Deletion studies show that loss of either Lkb1 (Lkb(+/–)) or Pten (Pten(loxP/loxP); Alb‐Cre(+)) leads to...

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Detalles Bibliográficos
Autores principales: Jia, Chengyou, Medina, Vivian, Liu, Chenchang, He, Lina, Qian, Daohai, Tu, Taojian, Okamoto, Curtis T., Stiles, Bangyan L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2017
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5687583/
https://www.ncbi.nlm.nih.gov/pubmed/29152604
http://dx.doi.org/10.1002/hep4.1027

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5687583/
https://www.ncbi.nlm.nih.gov/pubmed/29152604
http://dx.doi.org/10.1002/hep4.1027

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