Novel galeterone analogs act independently of AR and AR-V7 for the activation of the unfolded protein response and induction of apoptosis in the CWR22Rv1 prostate cancer cell model

The androgen receptor (AR) has long been the primary target for the treatment of prostate cancer (PC). Despite continuous efforts to block AR activity through ligand depletion, AR antagonism, AR depletion and combinations thereof, advanced PC tumors remain resilient. Herein, we evaluate two galetero...

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Detalles Bibliográficos
Autores principales: McCarty, David J., Huang, Weiliang, Kane, Maureen A., Purushottamachar, Puranik, Gediya, Lalji K., Njar, Vincent C.O.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5687622/
https://www.ncbi.nlm.nih.gov/pubmed/29179452
http://dx.doi.org/10.18632/oncotarget.19762

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5687622/
https://www.ncbi.nlm.nih.gov/pubmed/29179452
http://dx.doi.org/10.18632/oncotarget.19762

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