Characterizing the conformational landscape of MDM2-binding p53 peptides using Molecular Dynamics simulations

The conformational landscapes of p53 peptide variants and phage derived peptide (12/1) variants, all known to bind to MDM2, are studied using hamiltonian replica exchange molecular dynamics simulations. Complementing earlier observations, the current study suggests that the p53 peptides largely foll...

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Detalles Bibliográficos
Autores principales: Yadahalli, Shilpa, Li, Jianguo, Lane, David P., Gosavi, Shachi, Verma, Chandra S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5688104/
https://www.ncbi.nlm.nih.gov/pubmed/29142290
http://dx.doi.org/10.1038/s41598-017-15930-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5688104/
https://www.ncbi.nlm.nih.gov/pubmed/29142290
http://dx.doi.org/10.1038/s41598-017-15930-4

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