Millisecond dynamics of BTK reveal kinome-wide conformational plasticity within the apo kinase domain

Bruton tyrosine kinase (BTK) is a key enzyme in B-cell development whose improper regulation causes severe immunodeficiency diseases. Design of selective BTK therapeutics would benefit from improved, in-silico structural modeling of the kinase’s solution ensemble. However, this remains challenging d...

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Detalles Bibliográficos
Autores principales: Sultan, Mohammad M., Denny, Rajiah Aldrin, Unwalla, Ray, Lovering, Frank, Pande, Vijay S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5688120/
https://www.ncbi.nlm.nih.gov/pubmed/29142210
http://dx.doi.org/10.1038/s41598-017-10697-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5688120/
https://www.ncbi.nlm.nih.gov/pubmed/29142210
http://dx.doi.org/10.1038/s41598-017-10697-0

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