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Millisecond dynamics of BTK reveal kinome-wide conformational plasticity within the apo kinase domain
Bruton tyrosine kinase (BTK) is a key enzyme in B-cell development whose improper regulation causes severe immunodeficiency diseases. Design of selective BTK therapeutics would benefit from improved, in-silico structural modeling of the kinase’s solution ensemble. However, this remains challenging d...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5688120/ https://www.ncbi.nlm.nih.gov/pubmed/29142210 http://dx.doi.org/10.1038/s41598-017-10697-0 |