Crystal structure of the N-terminal domain of human CDC73 and its implications for the hyperparathyroidism-jaw tumor (HPT-JT) syndrome

CDC73/Parafibromin is a critical component of the Paf1 complex (PAF1C), which is involved in transcriptional elongation and histone modifications. Mutations of the human CDC73/HRPT2 gene are associated with hyperparathyroidism-jaw tumor (HPT-JT) syndrome, an autosomal dominant disorder. CDC73/parafi...

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Detalles Bibliográficos
Autores principales: Sun, Wei, Kuang, Xiao-Lin, Liu, Yan-Ping, Tian, Li-Fei, Yan, Xiao-Xue, Xu, Wenqing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5688130/
https://www.ncbi.nlm.nih.gov/pubmed/29142233
http://dx.doi.org/10.1038/s41598-017-15715-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5688130/
https://www.ncbi.nlm.nih.gov/pubmed/29142233
http://dx.doi.org/10.1038/s41598-017-15715-9

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