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Crystal structure of the N-terminal domain of human CDC73 and its implications for the hyperparathyroidism-jaw tumor (HPT-JT) syndrome
CDC73/Parafibromin is a critical component of the Paf1 complex (PAF1C), which is involved in transcriptional elongation and histone modifications. Mutations of the human CDC73/HRPT2 gene are associated with hyperparathyroidism-jaw tumor (HPT-JT) syndrome, an autosomal dominant disorder. CDC73/parafi...
Autores principales: | Sun, Wei, Kuang, Xiao-Lin, Liu, Yan-Ping, Tian, Li-Fei, Yan, Xiao-Xue, Xu, Wenqing |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5688130/ https://www.ncbi.nlm.nih.gov/pubmed/29142233 http://dx.doi.org/10.1038/s41598-017-15715-9 |
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