PTEN is a protein phosphatase that targets active PTK6 and inhibits PTK6 oncogenic signaling in prostate cancer

PTEN activity is often lost in prostate cancer. We show that the tyrosine kinase PTK6 (BRK) is a PTEN substrate. Phosphorylation of PTK6 tyrosine 342 (PY342) promotes activation, while phosphorylation of tyrosine 447 (PY447) regulates auto-inhibition. Introduction of PTEN into a PTEN null prostate c...

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Detalles Bibliográficos
Autores principales: Wozniak, Darren J., Kajdacsy-Balla, Andre, Macias, Virgilia, Ball-Kell, Susan, Zenner, Morgan L., Bie, Wenjun, Tyner, Angela L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5688148/
https://www.ncbi.nlm.nih.gov/pubmed/29142193
http://dx.doi.org/10.1038/s41467-017-01574-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5688148/
https://www.ncbi.nlm.nih.gov/pubmed/29142193
http://dx.doi.org/10.1038/s41467-017-01574-5

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