Elevated p53 Activities Restrict Differentiation Potential of MicroRNA-Deficient Pluripotent Stem Cells

Pluripotent stem cells (PSCs) deficient for microRNAs (miRNAs), such as Dgcr8(−/−) or Dicer(−/–) embryonic stem cells (ESCs), contain no mature miRNA and cannot differentiate into somatic cells. How miRNA deficiency causes differentiation defects remains poorly understood. Here, we report that miR-3...

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Detalles Bibliográficos
Autores principales: Liu, Zhong, Zhang, Cheng, Skamagki, Maria, Khodadadi-Jamayran, Alireza, Zhang, Wei, Kong, Dexin, Chang, Chia-Wei, Feng, Jingyang, Han, Xiaosi, Townes, Tim M., Li, Hu, Kim, Kitai, Zhao, Rui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5688240/
https://www.ncbi.nlm.nih.gov/pubmed/29141234
http://dx.doi.org/10.1016/j.stemcr.2017.10.006

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5688240/
https://www.ncbi.nlm.nih.gov/pubmed/29141234
http://dx.doi.org/10.1016/j.stemcr.2017.10.006

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