Cargando…

Proteotoxic Stress Desensitizes TGF-beta Signaling Through Receptor Downregulation in Retinal Pigment Epithelial Cells

BACKGROUND: Proteotoxic stress and transforming growth factor (TGFβ)-induced epithelial-mesenchymal transition (EMT) are two main contributors of intraocular fibrotic disorders, including proliferative vitreoretinopathy (PVR) and proliferative diabetic retinopathy (PDR). However, how these two facto...

Descripción completa

Detalles Bibliográficos
Autores principales:	Tan, X., Chen, C., Zhu, Y., Deng, J., Qiu, X., Huang, S., Shang, F., Cheng, B., Liu, Y.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Bentham Science Publishers 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5688417/ https://www.ncbi.nlm.nih.gov/pubmed/28625142 http://dx.doi.org/10.2174/1566524017666170619113435

Ejemplares similares

Upregulation of GADD45α in light-damaged retinal pigment epithelial cells
por: Gao, M-L, et al.
Publicado: (2016)

Proteotoxic stress targeted therapy (PSTT)
por: Sherman, Michael Y.
Publicado: (2011)

HSPB1 Is Essential for Inducing Resistance to Proteotoxic Stress in Beta-Cells
por: Gomes, Vinícius M., et al.
Publicado: (2021)

Quinotrierixin inhibits proliferation of human retinal pigment epithelial cells
por: Chen, Chen, et al.
Publicado: (2013)

Receptor downregulation and desensitization enhance the information processing ability of signalling receptors
por: Shankaran, Harish, et al.
Publicado: (2007)

Role of LINC01592 in TGF-β1-induced epithelial-mesenchymal transition of retinal pigment epithelial cells
por: Su, Ying, et al.
Publicado: (2021)

Inhibition of APE1/Ref-1 redox activity rescues human retinal pigment epithelial cells from oxidative stress and reduces choroidal neovascularization
por: Li, Y., et al.
Publicado: (2014)

Novel NADPH oxidase inhibitor VAS2870 suppresses TGF-β-dependent epithelial-to-mesenchymal transition in retinal pigment epithelial cells
por: Yang, Jing, et al.
Publicado: (2018)

Suppression of PGC-1α Drives Metabolic Dysfunction in TGFβ2-Induced EMT of Retinal Pigment Epithelial Cells
por: Shu, Daisy Y., et al.
Publicado: (2021)

Inhibition of NF-κB in astrocytes is sufficient to delay neurodegeneration induced by proteotoxicity in neurons
por: Li, Y. X., et al.
Publicado: (2018)

Gremlin in the Vitreous of Patients with Proliferative Diabetic Retinopathy and the Downregulation of Gremlin in Retinal Pigment Epithelial Cells
por: Qin, Dong, et al.
Publicado: (2020)

Aneuploidy and proteotoxic stress in cancer
por: Donnelly, Neysan, et al.
Publicado: (2015)

The effect of docetaxel on retinal pigment epithelial cells
por: Li, Jialin, et al.
Publicado: (2022)

Proteotoxic stress disrupts epithelial integrity by inducing MTOR sequestration and autophagy overactivation
por: Cheng, Xiaoxiang, et al.
Publicado: (2022)

Gremlin mediates the TGF-β-induced induction of profibrogenic genes in human retinal pigment epithelial cells
por: Qin, Dong, et al.
Publicado: (2020)

Serpentine retinal pigment epithelial tear
por: Maitray, Aditya, et al.
Publicado: (2021)

Human retinal pigment epithelial cells
por: Wang, Lei, et al.
Publicado: (2021)

Effectively Intervening Epithelial-Mesenchymal Transition of Retinal Pigment Epithelial Cells With a Combination of ROCK and TGF-β Signaling Inhibitors
por: Chen, Yi, et al.
Publicado: (2021)

Cardiac Fibrosis in Proteotoxic Cardiac Disease is Dependent Upon Myofibroblast TGF‐β Signaling
por: Bhandary, Bidur, et al.
Publicado: (2018)

Abnormal expression of TGF-beta type II receptor isoforms contributes to acute myeloid leukemia
por: Wu, Yong, et al.
Publicado: (2016)

Troglitazone suppresses transforming growth factor beta-mediated fibrogenesis in retinal pigment epithelial cells
por: Cheng, Huey-Chuan, et al.
Publicado: (2008)

Retinal pigment epithelial cells undergoing mitotic catastrophe are vulnerable to autophagy inhibition
por: Lee, S Y, et al.
Publicado: (2014)

Presence and regulation of cannabinoid receptors in human retinal pigment epithelial cells
por: Wei, Yan, et al.
Publicado: (2009)

Enhancing proteotoxic stress as an anticancer strategy
por: Grant, Steven
Publicado: (2011)

Effect of bradykinin on TGF-β1-induced retinal pigment epithelial cell proliferation and extracellular matrix secretion
por: Cai, Wenting, et al.
Publicado: (2016)

Autophagy regulates TGF-β2-induced epithelial-mesenchymal transition in human retinal pigment epithelium cells
por: Wu, Jing, et al.
Publicado: (2018)

Interleukin‐2 induces extracellular matrix synthesis and TGF‐β2 expression in retinal pigment epithelial cells
por: Jing, Ruihua, et al.
Publicado: (2019)

Proteotoxicity and Neurodegenerative Diseases
por: Ruz, Clara, et al.
Publicado: (2020)

Protective effect of autophagy on human retinal pigment epithelial cells against lipofuscin fluorophore A2E: implications for age-related macular degeneration
por: Zhang, J, et al.
Publicado: (2015)

Placental growth factor stabilizes VEGF receptor-2 protein in retinal pigment epithelial cells by downregulating glycogen synthase kinase 3 activity
por: Murata, Miyuki, et al.
Publicado: (2022)

Origins and consequences of hyperosmolar stress in retinal pigmented epithelial cells
por: Willermain, François, et al.
Publicado: (2014)

Inhibitory Effects of Plumbagin on Retinal Pigment Epithelial Cell Epithelial-Mesenchymal Transition In Vitro and In Vivo
por: Chen, Haitin, et al.
Publicado: (2018)

Foveolar simple retinal pigment epithelial hamartoma
por: Pujari, Amar, et al.
Publicado: (2018)

Acute Retinal Pigment Epitheliitis following Vaccination
por: Sasajima, Hirofumi, et al.
Publicado: (2022)

Propofol Decreases Endoplasmic Reticulum Stress–Mediated Apoptosis in Retinal Pigment Epithelial Cells
por: Zhou, Xuezhi, et al.
Publicado: (2016)

Restoration of mesenchymal retinal pigmented epithelial cells by TGFβ pathway inhibitors: implications for age-related macular degeneration
por: Radeke, Monte J., et al.
Publicado: (2015)

Proteotoxic Stress and Cell Death in Cancer Cells
por: Brancolini, Claudio, et al.
Publicado: (2020)

Mitochondrial metabolism promotes adaptation to proteotoxic stress
por: Tsvetkov, Peter, et al.
Publicado: (2019)

Transcriptional lockdown during acute proteotoxic stress
por: Sawarkar, Ritwick
Publicado: (2022)

Efficient downregulation of VEGF in retinal pigment epithelial cells by integrin ligand-labeled liposome-mediated siRNA delivery
por: Chen, Cheng-Wei, et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_f0o12eot1br9e26ffq4tr0qnrq