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ZIKV infection effects changes in gene splicing, isoform composition and lncRNA expression in human neural progenitor cells

BACKGROUND: The Zika virus (ZIKV) is a mosquito-borne flavivirus that causes microcephaly and Guillain-Barré syndrome in infected individuals. To obtain insights into the mechanism of ZIKV infection and pathogenesis, we analyzed the transcriptome of ZIKV infected human neural progenitor cells (hNPCs...

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Detalles Bibliográficos
Autores principales: Hu, Benxia, Huo, Yongxia, Yang, Liping, Chen, Guijun, Luo, Minhua, Yang, Jinlong, Zhou, Jumin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5688814/
https://www.ncbi.nlm.nih.gov/pubmed/29116029
http://dx.doi.org/10.1186/s12985-017-0882-6