Biochemical and structural bioinformatics studies of fungal CutA nucleotidyltransferases explain their unusual specificity toward CTP and increased tendency for cytidine incorporation at the 3′-terminal positions of synthesized tails

Noncanonical RNA nucleotidyltransferases (NTases), including poly(A), poly(U) polymerases (PAPs/PUPs), and C/U-adding enzymes, modify 3′-ends of different transcripts affecting their functionality and stability. They contain PAP/OAS1 substrate-binding domain (SBD) with inserted NTase domain. Aspergi...

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Detalles Bibliográficos
Autores principales: Kobyłecki, Kamil, Kuchta, Krzysztof, Dziembowski, Andrzej, Ginalski, Krzysztof, Tomecki, Rafał
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5689010/
https://www.ncbi.nlm.nih.gov/pubmed/28947555
http://dx.doi.org/10.1261/rna.061010.117

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5689010/
https://www.ncbi.nlm.nih.gov/pubmed/28947555
http://dx.doi.org/10.1261/rna.061010.117

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