Implications of PI3K/AKT inhibition on REST protein stability and neuroendocrine phenotype acquisition in prostate cancer cells

Treatment-induced neuroendocrine prostate cancer (t-NEPC) is an aggressive subtype of prostate cancer (PCa) that arises as a consequence of rigorous androgen receptor (AR) pathway inhibition (ARPI) therapies. While the PI3K/AKT pathway has been investigated as a co-therapeutic target with ARPI for a...

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Detalles Bibliográficos
Autores principales: Chen, Ruiqui, Li, Yinan, Buttyan, Ralph, Dong, Xuesen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5689579/
https://www.ncbi.nlm.nih.gov/pubmed/29156689
http://dx.doi.org/10.18632/oncotarget.19386

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5689579/
https://www.ncbi.nlm.nih.gov/pubmed/29156689
http://dx.doi.org/10.18632/oncotarget.19386

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