PDAC-derived exosomes enrich the microenvironment in MDSCs in a SMAD4-dependent manner through a new calcium related axis

Tumor genetics and escape from immune surveillance concur in the poor prognosis of PDAC. In this study an experimental model was set up to verify whether SMAD4, deleted in about 55% PDAC and associated with poor prognosis, is involved in determining immunosuppression through Exosomes (Exo). Potentia...

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Detalles Bibliográficos
Autores principales: Basso, Daniela, Gnatta, Elisa, Padoan, Andrea, Fogar, Paola, Furlanello, Sara, Aita, Ada, Bozzato, Dania, Zambon, Carlo-Federico, Arrigoni, Giorgio, Frasson, Chiara, Franchin, Cinzia, Moz, Stefania, Brefort, Thomas, Laufer, Thomas, Navaglia, Filippo, Pedrazzoli, Sergio, Basso, Giuseppe, Plebani, Mario
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5689584/
https://www.ncbi.nlm.nih.gov/pubmed/29156694
http://dx.doi.org/10.18632/oncotarget.20863

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5689584/
https://www.ncbi.nlm.nih.gov/pubmed/29156694
http://dx.doi.org/10.18632/oncotarget.20863

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