Combined BRD4 and CDK9 inhibition as a new therapeutic approach in malignant rhabdoid tumors

Rhabdoid tumors are caused by the deletion of SMARCB1, whose protein encodes the SMARCB1 subunit of the chromatin remodeling complex SWI/SNF that is involved in global chromatin organization and gene expression control. Simultaneously inhibiting the main players involved in the deregulated transcrip...

Descripción completa

Detalles Bibliográficos
Autores principales: Moreno, Natalia, Holsten, Till, Mertins, Julius, Zhogbi, Annabelle, Johann, Pascal, Kool, Marcel, Meisterernst, Michael, Kerl, Kornelius
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5689588/
https://www.ncbi.nlm.nih.gov/pubmed/29156698
http://dx.doi.org/10.18632/oncotarget.18583

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5689588/
https://www.ncbi.nlm.nih.gov/pubmed/29156698
http://dx.doi.org/10.18632/oncotarget.18583

Ejemplares similares