Cargando…
Combined BRD4 and CDK9 inhibition as a new therapeutic approach in malignant rhabdoid tumors
Rhabdoid tumors are caused by the deletion of SMARCB1, whose protein encodes the SMARCB1 subunit of the chromatin remodeling complex SWI/SNF that is involved in global chromatin organization and gene expression control. Simultaneously inhibiting the main players involved in the deregulated transcrip...
Autores principales: | , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Impact Journals LLC
2017
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5689588/ https://www.ncbi.nlm.nih.gov/pubmed/29156698 http://dx.doi.org/10.18632/oncotarget.18583 |