Preclinical efficacy of the novel competitive NAMPT inhibitor STF-118804 in pancreatic cancer

NAD salvage is one of the pathways used to generate NAD in mammals. Nicotinamide phosphoribosyltransferase (NAMPT), the rate-limiting enzyme in this pathway, uses nicotinamide (NAM) to generate nicotinamide mononucleotide (NMN). NMN is one of the main precursors of NAD synthesis in cells. Our previo...

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Detalles Bibliográficos
Autores principales: Espindola-Netto, Jair Machado, Chini, Claudia C.S., Tarragó, Mariana, Wang, Enfeng, Dutta, Shamit, Pal, Krishnendu, Mukhopadhyay, Debabrata, Sola-Penna, Mauro, Chini, Eduardo N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5689593/
https://www.ncbi.nlm.nih.gov/pubmed/29156703
http://dx.doi.org/10.18632/oncotarget.18841

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5689593/
https://www.ncbi.nlm.nih.gov/pubmed/29156703
http://dx.doi.org/10.18632/oncotarget.18841

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