Upregulation of CD11b and CD86 through LSD1 inhibition promotes myeloid differentiation and suppresses cell proliferation in human monocytic leukemia cells

LSD1 (Lysine Specific Demethylase1)/KDM1A (Lysine Demethylase 1A), a flavin adenine dinucleotide (FAD)-dependent histone H3K4/K9 demethylase, sustains oncogenic potential of leukemia stem cells in primary human leukemia cells. However, the pro-differentiation and anti-proliferation effects of LSD1 i...

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Detalles Bibliográficos
Autores principales: Fang, Jianwu, Ying, Haiyan, Mao, Ting, Fang, Yanjia, Lu, Yuan, Wang, He, Zang, Irene, Wang, Zhaofu, Lin, Ying, Zhao, Mengxi, Luo, Xiao, Wang, Zongyao, Zhang, Yan, Zhang, Chao, Xiao, Wei, Wang, Yan, Tan, Wei, Chen, Zhui, Lu, Chris, Atadja, Peter, Li, En, Zhao, Kehao, Liu, Jianfeng, Gu, Justin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5689595/
https://www.ncbi.nlm.nih.gov/pubmed/29156705
http://dx.doi.org/10.18632/oncotarget.18564

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5689595/
https://www.ncbi.nlm.nih.gov/pubmed/29156705
http://dx.doi.org/10.18632/oncotarget.18564

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