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A PP2A-mediated feedback mechanism controls Ca(2+)-dependent NO synthesis under physiological oxygen

Intracellular O(2) is a key regulator of NO signaling, yet most in vitro studies are conducted in atmospheric O(2) levels, hyperoxic with respect to the physiologic milieu. We investigated NO signaling in endothelial cells cultured in physiologic (5%) O(2) and stimulated with histamine or shear stre...

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Detalles Bibliográficos
Autores principales: Keeley, Thomas P., Siow, Richard C. M., Jacob, Ron, Mann, Giovanni E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Federation of American Societies for Experimental Biology 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5690389/
https://www.ncbi.nlm.nih.gov/pubmed/28760745
http://dx.doi.org/10.1096/fj.201700211R