Hi-fidelity discrimination of isomiRs using G-quadruplex gatekeepers

Core microRNA (miRNA) sequences exist as populations of variants called isomiRs made up of different lengths and nucleotide compositions. In particular, the short sequences of miRNA make single-base isomiR mismatches very difficult to be discriminated. Non-specific hybridizations often arise when DN...

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Detalles Bibliográficos
Autores principales: Seow, Nianjia, Fenati, Renzo A., Connolly, Ashley R., Ellis, Amanda V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5690596/
https://www.ncbi.nlm.nih.gov/pubmed/29145502
http://dx.doi.org/10.1371/journal.pone.0188163

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5690596/
https://www.ncbi.nlm.nih.gov/pubmed/29145502
http://dx.doi.org/10.1371/journal.pone.0188163

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