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Hi-fidelity discrimination of isomiRs using G-quadruplex gatekeepers
Core microRNA (miRNA) sequences exist as populations of variants called isomiRs made up of different lengths and nucleotide compositions. In particular, the short sequences of miRNA make single-base isomiR mismatches very difficult to be discriminated. Non-specific hybridizations often arise when DN...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5690596/ https://www.ncbi.nlm.nih.gov/pubmed/29145502 http://dx.doi.org/10.1371/journal.pone.0188163 |