The antiviral drug tenofovir, an inhibitor of Pannexin-1-mediated ATP release, prevents liver and skin fibrosis by downregulating adenosine levels in the liver and skin

BACKGROUND: Fibrosing diseases are a leading cause of morbidity and mortality worldwide and, therefore, there is a need for safe and effective antifibrotic therapies. Adenosine, generated extracellularly by the dephosphorylation of adenine nucleotides, ligates specific receptors which play a critica...

Descripción completa

Detalles Bibliográficos
Autores principales: Feig, Jessica L., Mediero, Aranzazu, Corciulo, Carmen, Liu, Hailing, Zhang, Jin, Perez-Aso, Miguel, Picard, Laura, Wilder, Tuere, Cronstein, Bruce
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5690602/
https://www.ncbi.nlm.nih.gov/pubmed/29145453
http://dx.doi.org/10.1371/journal.pone.0188135

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5690602/
https://www.ncbi.nlm.nih.gov/pubmed/29145453
http://dx.doi.org/10.1371/journal.pone.0188135

Ejemplares similares