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Allosteric modulation of cardiac myosin dynamics by omecamtiv mecarbil
New promising avenues for the pharmacological treatment of skeletal and heart muscle diseases rely on direct sarcomeric modulators, which are molecules that can directly bind to sarcomeric proteins and either inhibit or enhance their activity. A recent breakthrough has been the discovery of the myos...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5690683/ https://www.ncbi.nlm.nih.gov/pubmed/29108014 http://dx.doi.org/10.1371/journal.pcbi.1005826 |