An unexpected protein interaction promotes drug resistance in leukemia

The overall survival of patients with acute myeloid leukemia (AML) is poor and identification of new disease-related therapeutic targets remains a major goal for this disease. Here we show that expression of MPP1, a PDZ-domain-containing protein, highly correlated with ABCC4 in AML, is associated wi...

Descripción completa

Detalles Bibliográficos
Autores principales: Pitre, Aaron, Ge, Yubin, Lin, Wenwei, Wang, Yao, Fukuda, Yu, Temirov, Jamshid, Phillips, Aaron H., Peters, Jennifer L., Fan, Yiping, Ma, Jing, Nourse, Amanda, Sinha, Chandrima, Lin, Hai, Kriwacki, Richard, Downing, James R., Gruber, Tanja A., Centonze, Victoria E., Naren, Anjaparavanda P., Chen, Taosheng, Schuetz, John D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5691054/
https://www.ncbi.nlm.nih.gov/pubmed/29146910
http://dx.doi.org/10.1038/s41467-017-01678-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5691054/
https://www.ncbi.nlm.nih.gov/pubmed/29146910
http://dx.doi.org/10.1038/s41467-017-01678-y

Ejemplares similares