Autophagy acts through TRAF3 and RELB to regulate gene expression via antagonism of SMAD proteins

Macroautophagy can regulate cell signalling and tumorigenesis via elusive molecular mechanisms. We establish a RAS mutant cancer cell model where the autophagy gene ATG5 is dispensable in A549 cells in vitro, yet promotes tumorigenesis in mice. ATG5 represses transcriptional activation by the TGFβ-S...

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Detalles Bibliográficos
Autores principales: Newman, Alice C., Kemp, Alain J., Drabsch, Yvette, Behrends, Christian, Wilkinson, Simon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5691083/
https://www.ncbi.nlm.nih.gov/pubmed/29146913
http://dx.doi.org/10.1038/s41467-017-00859-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5691083/
https://www.ncbi.nlm.nih.gov/pubmed/29146913
http://dx.doi.org/10.1038/s41467-017-00859-z

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