Nucleosome acidic patch-targeting binuclear ruthenium compounds induce aberrant chromatin condensation

The ‘acidic patch’ is a highly electronegative cleft on the histone H2A–H2B dimer in the nucleosome. It is a fundamental motif for protein binding and chromatin dynamics, but the cellular impact of targeting this potentially therapeutic site with exogenous molecules remains unclear. Here, we charact...

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Detalles Bibliográficos
Autores principales: Davey, Gabriela E., Adhireksan, Zenita, Ma, Zhujun, Riedel, Tina, Sharma, Deepti, Padavattan, Sivaraman, Rhodes, Daniela, Ludwig, Alexander, Sandin, Sara, Murray, Benjamin S., Dyson, Paul J., Davey, Curt A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5691193/
https://www.ncbi.nlm.nih.gov/pubmed/29146919
http://dx.doi.org/10.1038/s41467-017-01680-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5691193/
https://www.ncbi.nlm.nih.gov/pubmed/29146919
http://dx.doi.org/10.1038/s41467-017-01680-4

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