An HIF-1α/VEGF-A Axis in Cytotoxic T Cells Regulates Tumor Progression

Cytotoxic T cells infiltrating tumors are thought to utilize HIF transcription factors during adaptation to the hypoxic tumor microenvironment. Deletion analyses of the two key HIF isoforms found that HIF-1α, but not HIF-2α, was essential for the effector state in CD8(+) T cells. Furthermore, loss o...

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Detalles Bibliográficos
Autores principales: Palazon, Asis, Tyrakis, Petros A., Macias, David, Veliça, Pedro, Rundqvist, Helene, Fitzpatrick, Susan, Vojnovic, Nikola, Phan, Anthony T., Loman, Niklas, Hedenfalk, Ingrid, Hatschek, Thomas, Lövrot, John, Foukakis, Theodoros, Goldrath, Ananda W., Bergh, Jonas, Johnson, Randall S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5691891/
https://www.ncbi.nlm.nih.gov/pubmed/29136509
http://dx.doi.org/10.1016/j.ccell.2017.10.003

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5691891/
https://www.ncbi.nlm.nih.gov/pubmed/29136509
http://dx.doi.org/10.1016/j.ccell.2017.10.003

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